Oxygen Dissociation Curve — Right vs Left Shift

Right shift = ↓ affinity (more O2 to tissues) Mnemonic: CADET, face Right • CO2 ↑ • Acid ↑ (low pH) • DPG ↑ (2,3-DPG) • Exercise • Temperature ↑ Left shift = ↑ affinity (O2 stays bound to Hb) • Opposite of above • Fetal Hb (HbF) • CO poisoning • Methaemoglobin • Alkalosis Bohr effect: pH/CO2 changes shift curve (Right shift in tissues) Haldane effect: deoxygenated Hb carries more CO2