Embryology
·Tetralogy of Fallot Components
Free
PROVe
Pulmonary stenosis, Right ventricular hypertrophy, Overriding aorta, VSD
Physiology
·Oxygen Dissociation Curve — Right Shift
Free
CADET, face Right!
CO2↑, Acid↑ (low pH), 2,3-DPG↑, Exercise, Temperature↑ → curve shifts right (decreased O2 affinity, more O2 to tissues)
Biochemistry
·Glycolysis Rate-Limiting Enzyme
Free
PFK-1 is the gatekeeper
Phosphofructokinase-1: rate-limiting step of glycolysis. Inhibited by ATP, citrate. Activated by AMP, fructose-2,6-bisphosphate
Pharmacology
·Cytochrome P450 Inhibitors
Free
SICKFACES.COM
Sodium valproate, Isoniazid, Cimetidine, Ketoconazole, Fluconazole, Alcohol (acute), Chloramphenicol, Erythromycin, Sulfonamides, Ciprofloxacin, Omeprazole, Metronidazole — CYP450 INHIBITORS (increase drug levels)
Pharmacology
·Anti-TB Drug Side Effects
Free
RIPE
Rifampicin (orange secretions, hepatitis), Isoniazid (peripheral neuropathy → give B6, hepatitis, drug-induced lupus), Pyrazinamide (hyperuricaemia, hepatitis), Ethambutol (optic neuritis)
Pathology
·Goodpasture Syndrome
Free
Anti-GBM in Goodpasture
Anti-glomerular basement membrane antibodies → linear IF on biopsy. Affects lungs (haemoptysis) + kidneys (RPGN). Type II hypersensitivity
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